When One Drug Is Not Enough: Evidence-Based Combination Approaches for Treatment-Resistant Erectile Dysfunction
For men who have tried sildenafil or tadalafil without satisfactory results, the clinical conversation should not end at monotherapy failure. A growing body of evidence supports rational combination strategies — incorporating agents such as L-citrulline, low-dose testosterone, and alpha-blockers — that address the multifactorial nature of refractory erectile dysfunction through synergistic mechanisms.